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E. Chiricozzi

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Open access Aug 2026

Label-free proteomic profiling identifies ECM-related alterations across regeneration states in human peripheral axonal neuropathies

Understanding the multiple mechanisms underlying peripheral nerve regeneration in humans is crucial for developing effective therapies for peripheral axonal neuropathies. Although in vitro and in vivo studies have provided significant insights, human studies exploring the composition of proteome remain limited. The ECM...

M. Damato, S. Aboulouard, Velia La Pesa et al. · 0 citations
Open access Jul 2026

Impaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndrome

Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene and characterized by profound impairments in neuronal maturation and synaptic connectivity. Increasing evidence indicates that astrocyte dysfunction contributes to RTT pathogenesis through non-cel...

Francesca M. Postogna, Noemi Giancroce, C. Cabasino et al. · 0 citations

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