E. de la Serna

Divergent genetic mediator signatures of adiposity-related metabolic liabilities and coronary artery disease.

Background. Obesity and leanness lie at opposite ends of the weight spectrum, yet both carry coronary risk when metabolically dysfunctional. A 2025 Commission redefined obesity around organ function rather than body mass, but whether that distinction reflects a difference in causal architecture, and whether the two hig...