Ferulic acid abrogates methotrexate-induced pulmonary injury by reducing inflammation and endoplasmic reticulum stress in rats.
Background The methotrexate (MTX) is employed in the treatment of various malignancies, including breast cancer and lymphoma, as well as chronic inflammatory diseases, but high doses can cause pulmonotoxicity. Ferulic acid (FEA) is a phenolic compound that has become a promising candidate for oxidative stress (OS) rela...