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Physiological Signatures Derived from Wrist Accelerometry Improve Detection of Isolated REM Sleep Behavior Disorder

Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of -synucleinopathies, but polysomnography is impractical for population-scale screening and questionnaires lack sufficient specificity. Beyond nocturnal movement, recently published models can derive sleep staging and other physiological sig...