Living scaffolds in monogenic genodermatoses: 3D skin models for physiopathology, gene therapy, and drug testing.
Keratinocytes have been cultured in vitro for more than 50 years to produce long-lasting epithelial grafts containing stem cells, transient amplifying progenitors, and differentiated cells. They have been widely used to study the molecular mechanisms underlying skin physiology, pathology (e.g. functional alterations ca...