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Open access Aug 2026

Paired Exome-Based Comprehensive Genomic Profiling and Germline Genetic Testing for Unselected Patients With Colorectal Cancer in a Multicenter Prospective Study

Background and Aims Comprehensive genomic profiling (CGP) for tumors and germline genetic testing (GGT) inform precision therapy and clinical management of patients with colorectal cancer (CRC), and evidence is growing in support of universal paired CGP-GGT patient testing. However, the utility of combining CGP and GGT...

P. L. Serrano Usón, Jacquelyn Reuther, M. Golafshar et al. · 0 citations
Open access Aug 2026

Risk-Reducing Interventions in Women With Pathogenic Variants in Breast Cancer Susceptibility Genes

PURPOSE Recommendations for clinical management of women with germline pathogenic variants (PVs) in breast cancer susceptibility genes vary by gene. The goal of this study was to examine the utilization of risk-reducing strategies and treatments in women with germline PVs in breast cancer susceptibility genes. METHODS...

Emily M. Russell, S. Nielsen, R. Ellsworth et al. · 0 citations

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