Review
Open access
Jul 2026
On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes
It is highlighted how specific variations of the canonical trypsin fold allow these five proteinases to display entirely distinct substrate specificities, and the role of allosteric mechanisms, such as exosites and dimerization, in expanding their substrate recognition profiles far beyond simple P1 cleavage site requir...
José Luis Gardeazábal-Torbado, E. Estébanez-Perpiñá, Pablo Fuentes-Prior
· Biological chemistry · 0 citations