Ferulic acid-mediated selenium nanoparticles attenuate oxaliplatin-induced renal injury in type 2 diabetic rats via modulation of oxidative stress, SIRT1/HMGB1/TLR4 signaling, endoplasmic reticulum stress, and apoptosis.
BACKGROUND Patients with type 2 diabetes mellitus (T2DM) are susceptible to chemotherapy-induced renal injury because of pre-existing oxidative stress, inflammation, and impaired antioxidant defenses. Ferulic acid-mediated selenium nanoparticles (FA-SeNPs) combine the antioxidant properties of ferulic acid with the bio...