Personalized medicine has redefined oncology by tailoring treatments to molecular and clinical characteristics. However, despite remarkable advances in biomarker discovery and targeted therapy, the integration of pharmacological principles into precision oncology remains limited. The resulting discrepancy between biolo...
V. Debien, A. Géraud-Crémieux, M. Le Grand et al.· ESMO Open· 0 citations
Although pre-analytical limitations remain to be fully characterized, integrating CRISPR into the diagnostic workflow may contribute to a rapid, cost-effective, and highly specific framework for the early detection of PDAC.
M. A. Rocco, Milda Kirvaitytė, Giulia Lencioni et al.· Cancer Letters· 0 citations
In surgically managed PDAC patients, young age and normal CA19-9 value carried independent favorable prognostic information, and prognosis was also shaped by nodal status, T stage, and receipt of adjuvant therapy.
I. Garajová, Bing-Zhi Wang, I. Chen et al.· Life· 0 citations
Current knowledge on molecular resistance to RAS-directed inhibitors in PDAC is summarized, organized into five categories: intrinsic resistance, KRAS-dependent mechanisms, KRAS-independent bypass signaling, downstream pathway reactivation, and tumor microenvironment (TME)-mediated resistance.
M. Pagano Mariano, Enrica Sgarilli, Dirk Mijnlieff et al.· Cancer Drug Resistance· 0 citations
The results demonstrated the therapeutic potential of PGP in tumor-growth reduction, indicating its potential value as a new approach in the treatment of colorectal-cancer.
Aida Yavari Kondori, Mehrdad Ahmadi, S. Nazari et al.· Clinical Cancer Research· 0 citations
An AI-based platform that combines multiple screening modalities with AI-driven digital analysis for identification of high-risk individuals to improve cancer screening, support clinical decision-making, reduce cancer risk, and optimize healthcare resources is developed.
Aida Yavari Kondori, Ahmadreza Tavasouli, Mona Maftouh et al.· Clinical Cancer Research· 0 citations
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