Alzheimer’s disease (AD) shows sex differences in prevalence, progression, and disease phenotypes, and molecular studies routinely report hundreds of sex-associated genes in the AD cortex. Most of these reports quantify the difference between the sexes within a diagnostic group, or compare gene lists obtained by...
Rebecca Ting Jiin Loo, Mohamed Soudy, G. Svinin et al.· Acta Neuropathologica Commun...· 0 citations
It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.
Audrey Coulon, F. Rabiller, M. Takalo et al.· Nature Genetics· 0 citations
An integrative multi-omics reanalysis of single-cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in Parkinson's disease and to generate new bulk ATAC-seq profiles from peripheral monocytes to assess whether these alterations extend to a systemi...
Mirco Macchi, A. Ginolhac, Tony Heurtaux et al.· Movement Disorders· 0 citations
Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.
Lisa M. Smits, S. Magni, K. Grzyb et al.· npj Parkinson's Disease· 0 citations
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