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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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E. Gorostieta-Salas

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Open access Oct 2026

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer’s disease neurons

Metabolic alterations and dysregulated alternative RNA splicing are central layers of Alzheimer’s disease (AD) pathogenesis, yet whether and to what extent these changes are mechanistically linked in adult human neurons in the aging brain remains unclear. To assess this, we generated induced neurons (iNs) by direct con...

Larissa Traxler, Oliver Borgogno, Kylie Champion et al. · 0 citations

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