E. H. Sadykov

Synthesis, Z/E Isomerism, and Cytotoxic Activity of β-Hydroxy Oximes Derived from Indenoquinoxalinone, Tryptanthrin, and a Tricyclic Isatin Analogue: A Combined Experimental and DFT Study

Indolo[2,3-b]quinoxalines and their N-substituted derivatives exhibit anticancer activity. In this work, a convenient two-step protocol comprising base-promoted aldol condensation followed by oximation was used for the synthesis of novel β-hydroxy oximes from heterocyclic ketones. The oximes were obtained as Z/E mixtur...