Open access
Jul 2026
PRRC2A-mediated m6A modification on NCOA4 promotes thymic epithelial tumor progression through PKM2-induced glycolysis
In vivo experiments showed that inhibition of PRRC2A suppressed tumor growth and metastasis in TETs, while combined treatment with the PKM2 inhibitor C599 and PRRC2A knockdown produced enhanced antitumor effects, suggesting that the PRRC2A-NCOA4-PKM2 axis represents a promising therapeutic target.
Tao Wang, Lang Xia, Lei Zhang et al.
· Cell Death and Disease · 0 citations