Author

E. Haura

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Sep 2026

KRAS-G12C inhibition-induced enrichment of MHC-Ihigh immune-active tumor cells directs immune-effector TME development to augment therapeutic efficacy.

Inhibition of KRASG12C (G12Ci) has shown promising clinical activity in several cancers; however, emergence of resistance is a major limitation to long-term benefit. It remains unknown how G12Ci impacts the tumor immune microenvironment and its association with resistance. We investigated the immune modulatory impact o...

Mohammed L. Ibrahim, Dana Foresman, Hong Zheng et al. · Cancer immunology research · 0 citations

Open access Aug 2026

Integrating molecular dynamics and machine learning to identify potential apo-state conformational and solvent-exposure signatures associated with resistant KRAS mutants

A computational framework integrating molecular dynamics (MD)-derived structural, energetic, thermodynamic, and contact-based descriptors with machine learning may inform the design of inhibitors targeting secondary KRAS resistance mutations, pending validation in additional structurally independent mutant systems.

Katarzyna Mizgalska, Konstancja Urbaniak, Denis Imbody et al. · Frontiers in Chemical Biolog... · 0 citations