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Author

E. Heinzen

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Open access Jul 2026

DEPDC5: Modeling of the Two-Hit Wonder in Cortical Organoids

A proof-of-concept model of DEPDC5 two-hit inactivation mosaicism is presented using patient-derived human cortical organoids (hCOs), highlighting that mosaic bi-allelic inactivation of the gene is necessary for FCDII pathogenesis.

E. Heinzen · 0 citations

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