Sickle cell disease (SCD) is a major haematological and health-system challenge in Africa, where a substantial global burden occurs alongside persistent limitations in access to safe and comprehensive transfusion services. Blood transfusion remains essential for selected acute complications, perioperative support, stro...
Bone marrow infiltration (BMI) by breast cancer cells is an early and critical step in the metastatic cascade that significantly impacts patient prognosis. The bone marrow microenvironment serves as a sanctuary for disseminated tumor cells, allowing them to survive, evade treatment, and potentially lead to disease recu...
E. I. Obeagu, Bibek Giri· International journal of med...· 0 citations
Chromosomal translocations are central drivers of hematologic malignancies, reshaping gene regulation, altering epigenetic states, and generating oncogenic fusion proteins that initiate and sustain malignant transformation. Advances in whole-genome sequencing, long-read mapping, and single-cell multiomics have expanded...
E. I. Obeagu, Abraham John Chuwkwuebuka, E. Abdalhabib· Universal Journal of Pharmac...· 0 citations
Erythropoietin is a glycoprotein hormone traditionally recognized for its central role in regulating erythropoiesis. Increasing evidence, however, highlights its pleiotropic effects in immunity, inflammation, and cellular protection, which are particularly relevant in the pathogenesis of human immunodeficiency virus in...
E. I. Obeagu, Okwudili B. Nwankwo· IOASD Journal of Medical and...· 0 citations
A review examines the current state of AI applications leveraging routine blood test parameters—including hematological and biochemical markers—to predict breast cancer risk, and finds promising results.
E. I. Obeagu· Asian Journal of Dental and...· 0 citations
Ovarian cancer is a highly heterogeneous malignancy with complex molecular underpinnings that extend beyond genomic mutations to encompass transcriptomic and epigenomic alterations. Advances in next-generation sequencing and bioinformatics have enabled comprehensive profiling of gene expression patterns, non-coding RNA...
E. I. Obeagu· Annals of Medicine and Surge...· 0 citations
Continuous technological innovation, prospective multicenter validation, standardized testing protocols, and evidence-based clinical guidelines are essential to fully integrate ctDNA into routine precision breast cancer care.
E. I. Obeagu, C. Okafor· Breast Cancer: Basic and Cli...· 0 citations
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