E. Joffré

Novel phage-plasmid mediated mechanism of antibiotic heteroresistance in Escherichia coli

A novel mechanism of HR by gene copy number increase is identified and further elucidates the role of phage-plasmids in antibiotic resistance development and spread and shows that a piperacillin-tazobactam-selected increase in phage-plasmid copy number did not increase the rate of horizontal transfer of the phage-plasm...

Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in Escherichia coli