E. Krueger

Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility

The intestinal epithelium is exposed to diverse combinations of microbiota-derived compounds; however, the mechanisms by which the host integrates these signals remain poorly defined. Studying two highly abundant microbial metabolites, we identified the purine metabolite hypoxanthine as an effector metabolite that dire...