Lipids are fundamental components of the brain, crucial for synaptic transmission and signal propagation. Altered brain lipid composition is associated with common and rare neuropathologies, yet, the spatial organization of the mammalian brain lipidome remains insufficiently characterized compared to other modalities1–...
Luca Fusar Bassini, H. H. Schede, Laura Capolupo et al.· bioRxiv· 7 citations
In this work, we propose a structural variant of the Factorial Hidden Markov Model (FHMM) for the analysis of disease trajectories in patients with Type 2 diabetes mellitus (T2DM). The model represents a patient's latent health state as a combination of multiple independent, simultaneously evolving components, associat...
Alessandro Mari, E. Krymova, G. Obozinski et al.· 0 citations
The proposed empirical Bayes framework offers a general solution for training heteroscedastic neural models in situations where manual hyperparameter tuning is impractical, and it is anticipated that this framework can be applied to other domains that encounter comparable computational limitations.
Yousra El-Bachir, F. F. Van der Veken, D. Di Croce et al.· 0 citations
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