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Author

E. Leehr

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Open access Aug 2026

Negative expectations in major depression: Association with brain structure and course of illness.

BACKGROUND Negative expectations towards the future are frequently observed in patients with major depressive disorder (MDD) and linked to less favourable outcomes like worse treatment response and suicidal behaviours. Despite clinical significance, the neurobiological underpinnings of negative expectations remain larg...

Laila Noor, F. Stein, K. Brosch et al. · 0 citations
Open access Aug 2026

Emotional processing biases in the longitudinal course of major depressive disorder.

Negative biases in emotional processing are central to cognitive models of Major Depressive Disorder (MDD), yet it remains unclear whether negatively biased valence attribution covaries with depressive symptoms or represents a more stable vulnerability. In this longitudinal study, we examined emotional valence ratings...

Katharina Hierl, Liane Wollweber, H. Lemke et al. · 0 citations
Open access Sep 2026

Cognitive Reserve as a Stratification Factor for Cognitive Impairment and Disease Progression in Major Depressive Disorder.

The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.

M. Gruber, Henrike Renaud, M. Mauritz et al. · 0 citations
Open access Aug 2026

The timeline of brain aging in major depression: A prospective study from before first-onset to established illness

Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...

M. Konowski, A. Kraus, J. Goltermann et al. · 0 citations
Open access Jul 2026

Investigation of polygenic risk scores and subphenotypes in social anxiety disorder

Social anxiety disorder (SAD) is a common anxiety disorder (ANX) with moderate heritability that often co-occurs with other mental disorders. Until now, sample sizes in genetic analyses of SAD have been limited, so that the genetic basis of SAD and its subphenotypes is still largely unknown. In a large cohort comprisin...

L. Sindermann, Angelina Röhrig, F. David et al. · 0 citations
Open access Aug 2026

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans

This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.

L. Fehse, A. H. Ribeiro, N. Winter et al. · 0 citations

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