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E. Lespessailles

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Review Open access Aug 2026

Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis

Highlights What are the main findings? Piezo1 is a central mechanosensor linking pathological mechanical loading to mitochondrial dysfunction, impaired mitophagy, and immunometabolic dysregulation in osteoarthritis. Persistent Piezo1 activation may initiate a self-amplifying cascade involving calcium overload, mitochon...

H. Toumi, A. Almhdie-Imjabbar, E. Lespessailles · 0 citations

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