Author

E. Lion

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Open access Nov 2026

Case Report: Multimodal treatment of pediatric H3G34-mutant diffuse hemispheric glioma: a safety and feasibility case report combining precision medicine and tumor treating fields with conventional care

Diffuse hemispheric glioma, H3G34-mutant (H3G34-DHG) is a rare, highly malignant brain tumour with a dismal prognosis and a median time to progression (TTP) of 10 months with best available practice. We report a case of a 13-year-old boy with H3G34-DHG who underwent a multimodal treatment strategy, combining backbone c...

Toon van Genechten, A. Claviez, S. Oberbeck et al. · Frontiers in Oncology · 0 citations

Open access Aug 2026

IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting

Findings highlight the limitations of dual-targeting approaches and underscore the need for advanced engineering strategies to improve CAR NK cells beyond antigen targeting and cytokine support in the PDAC microenvironment.

Laura Gehrcken, J. Ott, Astrid Van Den Eynde et al. · Molecular therapy. Oncology · 1 citation

Review Open access Aug 2026

Inflammatory mechanisms in the AML bone marrow niche: From pathogenesis to therapy.

This review summarizes the current knowledge on inflammatory cytokines and signaling pathways in AML, focusing on their mechanisms of action and implications for immune tolerance and clonal hematopoiesis and the emerging therapeutic strategies targeting these pathways to improve clinical outcomes for patients with AML.

Toon Suls, E. Lion, Florian Van Oers et al. · Cytokine & growth factor rev... · 0 citations