Author

E. M. Berntsen

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Open access Sep 2026

Selective nigrosome vulnerability in Parkinson’s disease revealed by histology-anchored ultra-high-field quantitative MRI

Selective vulnerability is a hallmark of Parkinson’s disease (PD): post-mortem, dopamine-containing cell loss in the substantia nigra first and most severely affects calbindin-poor compartments termed nigrosomes. Testing this in vivo has been limited by circularity, as MRI studies have delineated nigrosomes from the sa...

Rui-Yi Li, E. Kirilina, PL Bazin et al. · bioRxiv · 0 citations

Open access Aug 2026

7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson's disease.

PURPOSE Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra (SN). Imaging biomarkers sensitive to nigral pathology are limited. This study evaluated susceptibility changes in the SN using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7...

R. G. Unsgård, K. E. Stige, A. L. Kristoffersen et al. · Neuroradiology · 0 citations