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Author

E. M. Ersever

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Review Open access Aug 2026

The exercise-induced irisin–BDNF axis: a systematic review of evidence and translational implications

Current evidence suggests the PGC-1alpha–FNDC5–irisin–BDNF axis may constitute a molecular link between skeletal muscle activity and brain health; causal conclusions are limited by the associative and largely preclinical nature of the evidence.

E. M. Ersever · 0 citations
Review Open access Aug 2026

Exercise-induced irisin-BDNF signaling in aging: implications for cognitive decline, sarcopenia, and neurodegeneration. A narrative review.

Resistance training and HIIT offer the most consistent evidence for attenuating age-related neurotrophic decline, although HIIT-specific data in older adults remain limited and warrant cautious interpretation.

E. M. Ersever · 0 citations

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