Author

E. Mancini

2 papers indexed here

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Open access Jul 2026

Structure-function studies of HRIKD-ΔKI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase

Structural and ligand-binding features of HRI are defined to support ongoing drug discovery efforts in blood cancer to support ongoing drug discovery efforts in blood cancer.

M. Rajasekaran, Jessica Booth, Damien Crepin et al. · bioRxiv · 1 citation

Open access Aug 2026

A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes

Together, these findings identify a previously uncharacterised regulatory element within the LMTK3 C-terminus and support a model in which Ser1258 phosphorylation modulates kinase domain interactions and LMTK3-driven oncogenic functions in BC.

Andrea Lauer Betrán, A. Agnarelli, Mark Samuels et al. · Cells · 0 citations