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Open access Oct 2026

Grading left ventricular diastolic function and filling pressure using artificial intelligence-enabled echocardiography

Assessment of left ventricular diastolic dysfunction (LVDD) and filling pressure is standard in echocardiography but remains time- and expertise-dependent. We evaluated the performance and prognostic significance of an artificial intelligence (AI)-enabled echocardiography for LVDD grading. An AI model was...

R. Loutati, M. Fiman, A. Amshalom et al. · 0 citations
Open access Oct 2026

Sex-specific impact of chronic kidney disease on mortality and dialysis in heart failure with metabolic syndrome

Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disorder defined by the overlapping burden of heart failure (HF), chronic kidney disease (CKD), diabetes, and obesity. Although sex differences in cardiovascular disease are increasingly recognized, sex-specific patterns of mortality and renal progressi...

D. Hochstein, R. Loutati, V. Copeland et al. · 0 citations
Open access Oct 2026

Improving outcomes in HFpEF with advanced CKD: temporal trends from the SHEBAHEART Registry

Patients with advanced chronic kidney disease (CKD) and heart failure (HF) are systematically underrepresented in clinical trials despite comprising a substantial proportion of real-world HF populations [1]. Whether contemporary care has translated into improved outcomes in this high-risk group particularly among...

D. Hochstein, D. Sternik, V. Copeland et al. · 0 citations
Open access Oct 2026

Adverse effect of left ventricular hypertrophy in women with heart failure

Left ventricular hypertrophy is a hallmark of adverse remodeling in heart failure (HF), yet commonly used echocardiographic measures provide limited insight into sex-specific risk. Interventricular septal (IVS) thickness is routinely measured, but its independent prognostic value and potential sex-related differe...

A. Kaplan, V. Copeland, R. Loutati et al. · 0 citations
Open access Oct 2026

Chronic kidney disease in metabolic syndrome and heart failure: elevated risk, underutilized therapies, and missed opportunities for improved outcomes

In patients with late-stage metabolic syndrome, CKD identifies a high-risk subgroup with a graded increase in mortality and dialysis risk compared with eGFR ≥60, and the heightened dialysis risk remained pronounced after accounting for competing death.

D. Hochstein, R. Loutati, V. Copeland et al. · 0 citations

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