Mapping the N/OFQ(1−13)-NH2 Address Domain to Identify G Protein-Biased NOP Receptor Agonists
The nociceptin/orphanin FQ peptide receptor (NOP) couples to G proteins and β-arrestins, but how the peptide address domain influences transducer preference remains unclear. We synthesized ninety N/OFQ(1−13)-NH2 analogues with acylated lysine-based or related non-natural residues at positions 5−13 and evaluated NOP−G...