Author

E. Mastrangelo

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Open access Oct 2026

Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer

Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501). Acc...

F. Cossu, Serena Virili, Bianca Braggiotti et al. · Protein Science · 0 citations

Open access Sep 2026

Linking the second messenger cyclic di-GMP signaling with the regulatory activity of the small RNA ErsA in Pseudomonas aeruginosa

Abstract Biofilm formation in Pseudomonas aeruginosa is regulated by intersecting signals from the envelope stress response and the cyclic di-GMP (c-di-GMP) second messenger network. We previously described that the envelope stress response sigma factor σ22 can simultaneously drive transcriptional activation and, via t...

S. Ferrara, T. Brignoli, Silvia Santoro et al. · Nucleic Acids Research · 0 citations