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Author

E. Medina

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Open access Aug 2026

Shank3 mutation disrupts the molecular signature of sleepiness across development

Background Sleep problems are common in autism, emerge early in life and reduce quality of life, yet the mechanistic link between autism and poor sleep remains unclear. Human and rodent data indicate that difficulty falling asleep is a core feature of autistic insomnia, pointing to impaired responses to sleepiness as t...

Elliot M. Wald, E. Medina, Caitlin Ottaway et al. · 0 citations
Open access Aug 2026

Shank3 mutation disrupts the molecular signature of sleepiness across development

The Shank3ΔC mutation impairs the molecular accumulation of and response to sleepiness, both by elevating oxidative stress responses and by blocking the age-typical upregulation of pathways that differ between juveniles and adults.

Elliot M. Wald, Elizabeth Medina, Caitlin Ottaway et al. · 0 citations

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