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Open access Sep 2026

Three Cases of Merkel Cell Carcinoma Treated With Lutetium-177 Oxodotreotide.

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with early metastasis and poor outcomes in the advanced stages. Immune checkpoint inhibitors (ICIs), particularly avelumab, represent the first-line therapy for metastatic MCC. However, effective treatment options after progression...

Michitoshi Kurisaki, E. Nakano, Y. Sakai et al. · 0 citations
Open access Oct 2026

Melanoma Recurrence Prediction Using a Tissue-Free Epigenomic Molecular Residual Disease Assay: a Multicenter Prospective Observational Study (COSMOS-MEL01).

Despite recent adoption of perioperative therapy for high-risk melanoma, its overall survival benefit remains unclear, highlighting the need for biomarkers to identify patients likely to benefit from treatment. Detection of circulating tumor DNA (ctDNA) after definitive treatment predicts recurrence, and emerging molec...

Yoshiaki Nakamura, K. Namikawa, D. Ogata et al. · 0 citations
Open access Sep 2026

Genomic Landscape of Primary and Secondary Cutaneous Angiosarcoma: A Single-Center Retrospective Cohort Analysis in Japan.

Cutaneous angiosarcoma (cAS) is an aggressive vascular malignancy comprising idiopathic primary cutaneous angiosarcoma (PCAS) and secondary cutaneous angiosarcoma (SCAS) arising after radiation therapy or chronic lymphedema. Comparative genomic analyses delineating these subtypes in Asian populations remain limited. We...

Wei-Ting Liu, Harutaka Seshimo, Tatsuto Inoue et al. · 0 citations

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