Author

E. Ngwoke

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Open access Aug 2026

Transfected plasmids have reduced expression in cells deficient in SEPTIN 9 or ESCRT proteins

Depletion of the ESCRT proteins VPS36 or ALIX resulted in especially dramatic reductions in transfected plasmid expression, which were accompanied by reduced colocalization between the transfected DNA and CHMP4, an ESCRT protein important for endosomal membrane remodeling during intraluminal vesicle formation.

E. Ngwoke, J. Hollien · bioRxiv · 0 citations