Author

E. Nossier

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Open access Aug 2026

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies

The combined biochemical, cellular, and computational findings support the proposed involvement of the EGFR/PI3K/mTOR signaling pathway in its antiproliferative activity and identify DNA gyrase as a potential antibacterial target.

Hagar S. El-Hema, Esraa M. Adel, W. El-Dougdoug et al. · Pharmaceutics · 0 citations

Aug 2026

Design, synthesis, antitumor estimation, and molecular docking of new imidazothiazolediones as potential dual EGFR and IDO1 inhibitors and apoptosis stimulators.

Findings highlight compound 5d as a promising lead candidate for further optimization and cellular mechanistic validation in anti-cancer drug discovery.

M. Sarg, Fatma G. Abdulrahman, Yasmin S. Sheta et al. · Bioorganic & Medicinal Chemi... · 0 citations