Author

E. Nossier

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Oct 2026

Benzodiazepine-based N,S-heterocyclic hybrids as multi-target therapeutic candidates for cancer and inflammation: enzymatic evaluation, cellular mechanistic studies, in vivo anti-inflammatory assessment, and computational investigations.

A series of eleven novel benzodiazepine-based N, S-heterocyclic hybrids incorporating thienothiazine and thienopyrimidine scaffolds was designed, synthesized, and characterized by spectroscopic and analytical techniques. Compounds 4 and 6 showed favorable selectivity against HCT-116 and MDA-MB-231 cells relative to nor...

Hagar S. El-Hema, M. A. Abed, M. A. Hawata et al. · Bioorganic chemistry (Print) · 0 citations

Open access Oct 2026

Indole-1,2,4-triazole mannich hybrids as dual anti-newcastle disease virus genotype VII D and antimicrobial agents: In ovo efficacy and computational profiling

Newcastle disease virus (NDV) remains a major threat to global poultry production, particularly when viral outbreaks are aggravated by secondary microbial infections. To address this challenge, a focused series of indole–1,2,4-triazole Mannich hybrids (4a–d, 5c–d, 6a–d, 7a–d, and 8a–b) was designed and synthesized as p...

Mohamed G. Abouelenein, Yasmin K. Elsersy, H. Abd-Alla et al. · Scientific Reports · 0 citations

Open access Aug 2026

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies

The combined biochemical, cellular, and computational findings support the proposed involvement of the EGFR/PI3K/mTOR signaling pathway in its antiproliferative activity and identify DNA gyrase as a potential antibacterial target.

Hagar S. El-Hema, Esraa M. Adel, W. El-Dougdoug et al. · Pharmaceutics · 0 citations

Aug 2026

Design, synthesis, antitumor estimation, and molecular docking of new imidazothiazolediones as potential dual EGFR and IDO1 inhibitors and apoptosis stimulators.

Findings highlight compound 5d as a promising lead candidate for further optimization and cellular mechanistic validation in anti-cancer drug discovery.

M. Sarg, Fatma G. Abdulrahman, Yasmin S. Sheta et al. · Bioorganic & Medicinal Chemi... · 0 citations