Post-traumatic stress disorder (PTSD) is associated with persistent dysregulation of cellular stress pathways and altered neuronal signaling within limbic and prefrontal circuits. Increasing evidence indicates that activation of endoplasmic reticulum stress responses, oxidative imbalance, and inflammasome signaling con...
E. Ogłodek· Polski merkuriusz lekarski :...· 0 citations
OBJECTIVE
Aim: The aim of this review is to summarize current knowledge on the interplay between immune activation and stress-response dysregulation in post-traumatic stress disorder, with particular emphasis on molecular and neurobiological mechanisms.
PATIENTS AND METHODS
Materials and Methods: This narrative revie...
Post-traumatic stress disorder (PTSD) is a multifactorial neuropsychiatric condition characterized by persistent disturbances in fear processing, emotional regulation, and memory. Increasing evidence indicates that dysregulation of glutamatergic neurotransmission plays a crucial role in both the development and persist...
E. Ogłodek· Polski merkuriusz lekarski :...· 0 citations
These findings support the concept that the processing of pro-inflammatory cytokine maturation and neuroimmune signaling is a central mechanism in PTSD rather than a secondary consequence of stress exposure.
Neuromolecular biomarkers may improve the current symptom-based diagnostic model of PTSD and their integration with clinical assessment tools may support identification of biologically defined subgroups and enable more targeted treatment.
E. Ogłodek· Wiadomosci lekarskie· 0 citations
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