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Aug 2026

Performance of deep learning auto-segmentation models for cardiac substructures in paediatric proton beam therapy

Accurate segmentation of cardiac chambers and substructures is fundamental for quantifying radiation exposure and studying late cardiovascular side-effects in children receiving thoracic radiotherapy. Manual segmentation is time consuming and subject to inter-observer variability, therefore limiting its use in ca...

L. Goyal, R. Bell, K. Banfill et al. · 0 citations
Aug 2026

Causal analysis of radiation dose to the base of the heart and overall survival in lung cancer using targeted maximum likelihood estimation

Radical radiotherapy is delivered with curative intent in approximately 40% of patients with lung cancer. The RTOG 0617 trial and subsequent studies demonstrated that higher cardiac radiation exposure is associated with increased mortality. As clinical equipoise precludes randomisation to different cardiac dose l...

B. Jiang, M. Summers, E. Osorio et al. · 0 citations

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