E. Osto

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lipid metabolism, and liver BA regulation in mice bearing...