Author

E. Plotnikov

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Open access Oct 2026

Development and study of a novel anti-HER2 therapeutic conjugate based on DARPin G3

Introduction. Overexpression of human epidermal growth factor receptor 2 (HER2) is a critical driver of malignancy in multiple solid tumors, underscoring the demand for innovative targeted therapeutics. Protein–drug conjugates offer selective delivery of highly potent cytotoxic payloads directly to tumor cells. Desi...

A. Prach, M. Larkina, S. Krivoshchekov et al. · Drug development & regis... · 0 citations

Open access Sep 2026

Synthesis, Z/E Isomerism, and Cytotoxic Activity of β-Hydroxy Oximes Derived from Indenoquinoxalinone, Tryptanthrin, and a Tricyclic Isatin Analogue: A Combined Experimental and DFT Study

Indolo[2,3-b]quinoxalines and their N-substituted derivatives exhibit anticancer activity. In this work, a convenient two-step protocol comprising base-promoted aldol condensation followed by oximation was used for the synthesis of novel β-hydroxy oximes from heterocyclic ketones. The oximes were obtained as Z/E mixtur...

A. V. Uvarov, E. Plotnikov, Daria D. Eskova et al. · Organics · 0 citations