Hispanic/Latinx (HL) women experience disproportionate breast cancer (BC) mortality and are more often diagnosed at younger ages with aggressive subtypes when compared to non-Hispanic White (NHW) women. While disparities likely result from the interaction of social and biologic factors, the contributions of socia...
N. Gyabaah-Kessie, S. Deshmukh, D. Álvarez-López et al.· Cancer Epidemiology, Biomark...· 0 citations
In advanced breast cancers, the highly suppressive tumor microenvironment contributes to poor responses to immune checkpoint inhibition. The degree of suppression varies by site of disease, which can affect metastatic progression. To investigate this phenomenon, we have developed an agent-based model of cell-cell inter...
Tyler King, E. Gonzalez, E. R. Roussos Torres et al.· bioRxiv· 0 citations
Overall, this study identifies lymphoid and myeloid cell contributions to response to treatment with HDAC inhibitors and immune checkpoint blockade, providing a framework for discovering interactions driving responses in complex TMEs.
E. Gonzalez, J. Kreger, Ying-Tong Liu et al.· Cancer Research· 0 citations
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