Author

E. S. Herini

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Open access Oct 2026

Serum HMGB1 and TLR4 Levels in Pediatric Drug-Resistant Epilepsy: Associations and Preliminary Discriminatory Performance

Purpose: Drug-resistant epilepsy (DRE) in children contributes substantially to morbidity and mortality. Neuroinflammation has been implicated in epilepsy pathogenesis, particularly in treatment resistance. High-mobility group box 1 (HMGB1) and Toll-like receptor 4 (TLR4) are key mediators of inflammatory signaling. HM...

A. P. Nugrahanto, A. Triono, D. Nurputra et al. · Annals of Child Neurology · 0 citations

Review Aug 2026

Whole-exome sequencing in pediatric drug-resistant epilepsy: diagnostic yield and clinical impact in a resource-limited setting

WES can yield a definitive genetic diagnosis in a subset of patients, enabling individualized management, facilitating genetic counseling, and reducing the need for further diagnostic investigations.

E. S. Herini, A. Triono, K. Iskandar et al. · Neurogenetics · 0 citations