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Author

E. Schueddig

3 papers indexed here

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Sep 2026

Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels.

BackgroundIn Alzheimer's disease (AD), tau protein aggregates to form neurofibrillary tangles (NFTs). The cellular changes favoring AD brain NFT formation remain incompletely understood. AD brains also display mitochondrial defects, including reduced mitochondrial DNA (mtDNA) copy number.ObjectiveWe considered whether...

Ian Weidling, E. Schueddig, Xiao-Wan Wang et al. · 0 citations
Open access Jul 2026

Integrative Modeling of Read Depth and B-Allele Frequency Improves Single-Cell Copy Number Calling from Targeted DNA Sequencing Panels

Copy number variations (CNVs) drive cancer initiation and progression, but resolving them at single-cell resolution from targeted DNA sequencing panels remains challenging. The Mission Bio Tapestri platform generates 2 complementary signals for CNV inference: sequencing depth and B-allele frequency (BAF) from heterozyg...

D. Pei, Rachel Griffard-Smith, Brahian Cano Urrego et al. · 0 citations
Open access Aug 2026

Mitochondrial tRNA-Derived Fragments as Candidate Metastasis-Modifying RNA

This study identifies and preliminarily characterize previously undescribed tRNA-derived fragments (tRF) generated from mt-TRs that are suspected to regulate metastasis efficiency and proposes that these tRFs may function as metastasis modifiers.

Katy L. Swancutt, R. M. Walsh, Sydney Quijano et al. · 0 citations

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