Obesity develops through progressive metabolic alterations that arise long before overt disease, highlighting the need for pharmacological strategies capable of targeting the earliest tissue adaptations to fat nutrient excess. Skeletal muscle plays a central role in systemic metabolic homeostasis and is among the first...
M. Friuli, B. Eramo, Nisha Zahid et al.· Pharmacological Research· 0 citations
Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and diagnostics, addressing the limitations of traditional cancer therapies. Integration of photodynamic therapy (PDT) with nanoparticle‐based DDSs has significantly improved the targeted accumulation and pharmacokinetic propert...
Athira Narayanan, Benedetta di Chiara Stanca, Daniela Pinheiro et al.· Visual Information Expert Wo...· 0 citations
Sustained PA/OA exposure induces a staged hepatocellular response, early lipid-buffering adaptation, intermediate metabolic compensation, and late decompensation, indicating that chronic lipotoxicity reflects progressive loss of regulatory coordination despite persistent metabolic adaptation.
I. Serra, Elisa Bisconti, Francesco Vari et al.· Journal of NutriLife· 0 citations
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