Open access
Sep 2026
Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearanc...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo et al.
· Experimental Physiology · 0 citations