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E. Vardy

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Review Sep 2026

Mechanisms of Aging in Phenylketonuria (PKU).

Phenylketonuria (PKU) is an autosomal recessive inherited metabolic disorder (IMD) characterized by elevated phenylalanine (Phe) levels, requiring a low-protein diet and low-Phe amino acid supplementation from birth to prevent cognitive impairment. Despite early and continuous treatment, emerging evidence indicates tha...

John Bassett, Neve Cufflin, Iain P Hargreaves et al. · 0 citations

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