E. Volkmann

Conceptual framework for the definition of disease modification in systemic sclerosis and potential implications for drug development and clinical study design.

Systemic sclerosis (SSc) is a multifaceted systemic autoimmune disease, characterised by the interplay of vascular alterations, immune dysregulation, and fibrosis. The molecular changes and the clinical presentation of SSc are highly heterogeneous and vary considerably between individual patients. This heterogeneity ha...