Author

E. Wolf

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Open access Sep 2026

Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model

The study describes the generation of a humanized pig model carrying an inducible phospholamban R14del mutation for cardiomyopathy modeling and demonstrates Cre-based activation strategies as efficient alternatives to germline Cre-driver lines in large animals.

Petra Runa-Vochozkova, M. Vaškovičová, J. Cambra et al. · Lab animal · 0 citations

Open access Sep 2026

A positively selected microRNA controls a reversible aging program in striated muscle

It is shown that antisense oligonucleotide-mediated inhibition of miR-128-3p restores muscle mass and function in aged mice, improves cardiac function while limiting adverse remodeling following myocardial infarction, and ameliorates skeletal and cardiac muscle pathology in mouse and pig models of Duchenne muscular dys...

Melissa A. Boldridge, Lei Xu, Xiao-Yin Wang et al. · bioRxiv · 0 citations

Review Aug 2026

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation.

These approaches offer promising strategies to expand the donor organ pool and address the growing global demand for transplantation and will be critical for widespread translation.

Asghar Ali, M. Kurome, Daniel Reichart et al. · Transplantation · 0 citations