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Author

E. Yángüez

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Open access Sep 2026

T-cell dynamics, CD8/NK ratio and tumor survival hallmarks determine response to T-cell bispecific forimtamig in myeloma.

T-cell bispecific (TCB) therapies have demonstrated promising therapeutic efficacies for patients with relapsed/refractory multiple myeloma. However, responses are transient and essentially all patients eventually relapse. Cytokine release syndrome and other on-target off-tumor toxicities are common. Together, these ch...

I. Dekhtiarenko, Jan Attig, I. Lelios et al. · 0 citations
Open access Aug 2026

PD-1-Targeted IL-2v Expands a Novel Stem-like T Cell Subset Distinct from Anti-PD-1 Therapy to Enhance Effector Differentiation

It is demonstrated that PD1-IL2v induces an early bifurcation in the differentiation of stem-like CD8⁺ T cells within tumor-draining lymph nodes, identifying an early branch point in stem-like T-cell differentiation and providing mechanistic insight into how PD1-IL2v circumvents exhaustion pathways to preferentially ge...

Elzbieta Gralinska, Caterina Scirgolea, Amrita Manchala et al. · 0 citations

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