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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Edgar H. H. Wong

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Open access Aug 2026

Chemically triggered bioorthogonal activation of antimicrobial peptide mimic prodrugs

A novel AMP mimic prodrug where the cationic ammonium residues are caged with trans-cyclooctene units that can be bioorthogonally activated by tetrazine via an inverse-electron-demand Diels–Alder click-to-release reaction is developed, demonstrating the on-demand control of toxicity enabled by the bioorthogonal trigger.

Hao Luo, Rhiannon P. Kuchel, Kevin Neumann et al. · 0 citations

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