Bioinformatic Prediction of Cellular Targets of Aminoestrones through Molecular Docking: Implications for Flavivirus Replication and Cell-to-Cell Transmission.
Background: Flaviviruses such as dengue virus and Zika virus rely on host cellular factors to complete their replication cycle. Host proteins involved in cytoskeleton dynamics and vesicular trafficking may represent potential therapeutic targets. Bioactive aminoestrones have shown antiviral activity, although their mol...