Eduarda Fernandes

Flavonoids and chalcones as selective α-glucosidase inhibitors: from enzymatic screening to validation using the human enzyme

α-Glucosidase is a key therapeutic target for postprandial glucose control, but most clinically available inhibitors also inhibit α-amylase, leading to gastrointestinal side effects. Natural polyphenols have been widely reported as potent and selective α-glucosidase inhibitors, primarily based on screening assays using...