Author

Eduardo P. C. Rocha

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Open access Sep 2026

Acquisition and erosion of toxin-antitoxin systems in bacterial chromosomes.

Toxin-antitoxin systems (TAs) are widespread in bacterial genomes. Yet, their integration, persistence, and impact in chromosome dynamics remain unclear. Here, we identified 80 type II TAs in the single chromosome of Photorhabdus laumondii TT01, 50 of which were experimentally validated. Comparative analysis across the...

Ludovic Belot, Amaury Payelleville, D. Jurėnas et al. · Molecular biology and evolut... · 0 citations

Open access Sep 2026

Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance

Plasmids are key drivers of bacterial adaptation, yet the mechanisms that generate their diversity remain poorly understood. Here, we show that mobile genetic elements (MGEs) orchestrate a fusion-deletion life cycle that repeatedly remodels plasmids in Staphylococcus aureus . Large-scale genomic analyses reveal t...

Thomas Ipoutcha, Yi-Qing Wang, Eduardo P. C. Rocha et al. · Nature Communications · 0 citations