Author

Edward A. Anderson

2 papers indexed here

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Sep 2026

Stereoselective polysubstituted bicyclo[1.1.0]butane synthesis by rhodium-catalyzed kinetic resolution.

Bicyclo[1.1.0]butanes (BCBs) are a distinctive class of strained small-ring carbocycles of growing importance in synthetic and medicinal chemistry. However, the enantioselective synthesis of polysubstituted BCBs remains a largely unsolved challenge. Herein, we report a general chemical platform for the stereoselective...

Xiao-Long Zhang, Rong-Kai Wu, Zhaohong Liu et al. · Science · 0 citations

Open access Jul 2026

A versatile strategy for oligonucleotide functionalization via on-support phosphitylation.

Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited...

Ayan Dasgupta, S. Golojuch, Li Xiao et al. · Nature Chemistry · 0 citations